In 2006, the drug trade is booming. The Malaysian Intelligence and Anti-Narcotic Department are called upon for assistance by their Indian counterparts. The Indian team is headed by DCP D'Silva (Boman Irani), who wants to break the drug operations of a drug lord named Singhania. Helping him along the way is Malik (Om Puri). Both of them know that in order to capture Singhania, they must capture his most loyal ally Don (Shahrukh Khan). Don is extremely dangerous - he has even been known to kill one of his own men Ramesh, who attempted to leave Don and his gang without informing Don first. Ramesh's fiance Kamini (Kareena Kapoor) decides to help D'Silva arrest Don but in the process, she is also killed by Don. Now, Ramesh's sister Roma (Priyanka Chopra) manages to get her way into Don's gang by persuading them that she is wanted by the police - her real plan is to murder Don in order to avenge her brother and his fiance.
Don and his gang, consisting of Anita (Eesha Koppikhar) his girlfriend and Narang (Pawan Malhotra) travel to India to trade some drugs. D'Silva and his team follow them there - Don is injured fatally during a police chase. D'Silva keeps this a secret - he decides to track down a look alike of Don named Vijay (also Shahrukh Khan) and asks him to pose as Don so that he (D'Silva) can get the gang arrested. Vijay agrees when D'Silva promises to admit Deepu (Tanay Chheda), a child Vijay looks after, to a good school. Meanwhile, Jasjit (Arjun Rampal), Deepu's real father has just been released from prison and becomes bent on killing D'Silva. This is because Jasjit was committing a crime in order to save Deepu and his wife from a gang of criminals and D'Silva had Jasjit arrested, thereby preventing Jasjit from saving his wife from death.
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